Researchers reviewed existing evidence from scientific studies showing that regular exercise, physical activity, and fitness may influence epigenetic aging and potentially reverse it, offering a promising way to extend healthspan and improve long-term health.

Antibiotics that target mitochondria extend lifespan in C. elegans (Nov 2023)

Chemically induced reprogramming to reverse cellular aging

Discovery of Chemical Means to Reverse Aging and Restore Cellular Function

Metabolic switch in the aging astrocyte supported via integrative approach comprising network and transcriptome analyses (Apr 2023)

Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail (Mar 2023)

Senolytic effect of high intensity interval exercise on human skeletal muscle (Feb 2023)

Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity (Feb 2023)

Chronic alcohol consumption increasingly seen as damaging to the brain and accelerates epigenetic aging

Aging attenuates diurnal lipid uptake by brown adipose tissue (Oct 2022)

Centenarians consistently present a younger epigenetic age than their chronological age with four epigenetic clocks based on a small number of CpG sites (Oct 2022)

Longevity pharmacology: Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine

For the first time, a non-pharmaceutical clinical trial has proven effective in reversing the main activators of Alzheimer’s disease, according to Tel Aviv University’s Prof

Deep-learning algorithms could be the key to efficient and non-invasive dementia detection

Exercise reduces metabolic burden while altering the immune system in aged mice

Hyperbaric oxygen therapy increases telomere length in isolated blood cells

Rejuvenation Of Three Germ Layers Tissues By Exchanging Old Blood Plasma With Saline-Albumin - An Anti-Aging Study Shows That Replacing Blood Could Extend Life

Habitual tea drinking modulates brain efficiency, suggests a new study that evaluated brain connectivity, the first compelling evidence that tea drinking positively contributes to brain structure making network organization more efficient.

Altogether, the study highlights that aging leads to a complex interplay between the microbiome and host physiology, and provides candidate microbial species to target physical and metabolic decline during aging by modulating gut microbial ecology.

Deep biomarkers of human aging: Application of deep neural networks to biomarker development