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First for RNA therapy: man with rare motor-neuron disease improves after treatment

Intestinal infections cause antigen-specific CD4+ T cells to migrate from the gut and establish long-lived memory in the brain and meninges, a mechanism the authors link to anxiety and depression in inflammatory bowel disease

Two parallel neural ectoderm progenitors contribute to the developing brain

Cholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria

Defining collectivism as duties in relationships rather than generalized warmth improves predictive validity in 100 cultures

Ca 5% of white adults in the US support white nationalism, but among young white men, it's 13.5%

Human brain cells transplanted into mice in ‘most extensive’ integration ever

Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate

In a US trial, teclistamab wiped out cancer completely in 78% of high risk myeloma patients, against 0% on standard treatment, and cut two year progression to 8%.

A divergent betacoronavirus with a functional furin cleavage site in South American bats

Teenage girls show higher prevalence of internalizing problems than boys: depressive symptoms (15.9% versus 8.2%) and suicidal ideation (29.8% versus 18.1%)

Emergent blink rate in early childhood is associated with neural origins of executive function

Higher semaglutide dose is associated with lower neuropsychiatric event incidence independent of weight loss

Researchers worry that generative AI is homogenizing culture and cognition

Targeting the best-connected buyers of green hydrogen makes subsidies up to 41% more cost-effective

Nos1 neurons in the paraventricular hypothalamic area modulate lipid metabolism via the sympathetic nervous system in male mice

A review of 1,624 estimates since the 1970s found scientists still cannot agree how much water the world's farms actually draw for irrigation, and the guesses are getting worse, not better.

YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutationsh

A survey of 3,751 Syrian and Iraqi refugees found that drought made war's mental toll worse.

Using data from 10 countries, researchers find that the expansion of high-paying finance jobs is a major driver of rising geographic inequality, not simply the growth of big cities.

PQBP1-dependent alternative RNA splicing underlies high calorie diet-induced cognitive impairmentbv

Pregnant mice crave food much as pregnant women report. Researchers traced it to serotonin brain cells that fire less during pregnancy.

Prenatal cannabis exposure was associated with alterations in large-scale functional brain network connectivity in late childhood, higher levels of psychopathology and significant differences across multiple cognitive domains, according to a study on 10,838 children (9-10 years)

In a prospective study of 104,806 adults followed for a median 8.1 years, greater differences in meal timing between weekdays and weekends were associated with higher cardiovascular disease risk in men

A global analysis from 1979–2023 found the first heatwave now arrives about two weeks earlier, the last ends 24 days later, and heatwave seasons have lengthened by roughly 39 days, with 92% of land areas showing a trend toward longer heatwave seasons.

'Epigenetic' editing banishes hepatitis B virus

Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer

Accelerometer data from 57 adults (and 17 wrist/hip data) tracked for 90 days suggests that participants with high cadence and high peak height in their gait were less likely to be depressed or anxious

Intratumoral T cell activation kills tumors regardless of T cell specificity | Nature Immunology

Modelling over 16,000 groundwater samples, researchers found wells near land vulnerable to shale gas spills were three times more likely to carry deep drilling fluid chemicals.

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