A new study in healthy mice reveals that the weight-loss drug semaglutide alters behavior and brain activity related to stress and reward, leading to a suppression of natural reward-seeking drives and faster…

Girls born to mothers who took acetaminophen (paracetamol) during pregnancy exhibited smaller uteri (−13%) & ovaries (−40%), fewer ovarian follicles (−23%)…

Nanobody-boosted human ASIC1a endocytosis alleviates chronic pain and anxiety-like behaviours

Remote-control robot cockroaches could deliver lifesaving aid to disaster victims

When inflammation evicts blood-making stem cells from bone marrow, they partner with calming T-cells

The Trump administration's proposed new 'Most-Favoured-Nation' Medicare pricing policies could reshape global pharmaceutical markets, potentially driving up prices and delaying medicine launches worldwide…

GLP-1 drugs may improve obstructive sleep apnea through mechanisms beyond weight loss, including effects on breathing control, upper-airway neuromuscular function, and inflammation

Arthritis drug restores up to 100% of hair growth in patients with severe alopecia, with researchers reporting significant regrowth in many participants and new hope for treating autoimmune hair loss.

Newly discovered stem cell reveals potential drug target for spinal stenosis: « Researchers at Weill Cornell Medicine and Hospital for Special Surgery have discovered the stem cells that give rise to the body’s tendons and ligaments…

Genetically modified pig kidney keeps man alive for record nine months

Gut microbiome development may help predict type 1 diabetes in children at high risk

The reduced risk of heart disease seen in people who are overweight or have obesity taking the weight loss drug semaglutide may not be due to a drop in weight alone

Blood tests could identify early signs of cancer years before diagnosis

A pill nearly halved deaths from head injury In a Swedish led trial in a low income hospital, 20% given the drug Salovum died within 30 days, against 39% on standard care

Experimental plague vaccines protected 80 to 100% of mice against lethal pneumonic plague, including mice engineered to lack interferon gamma, an immune signal long thought essential to surviving it

Researchers engineer novel nanotherapy to treat endometriosis; niclosamide (an anti-parasitic drug) paired with a nano-carrier targets immune cells associated with endometriosis lesions; study shows reduced symptoms and number of lesions after one dose using mouse model

Escitalopram significantly reduced anger and irritability in people with premenstrual dysphoric disorder (PMDD), according to new research, providing further evidence that the antidepressant may help alleviate some of the condition's most disruptive emotional symptoms.

MIT used AI to develop new recipe for mRNA vaccines so they no longer need freezers and can sit at room temp for a full year or survive about 100F heat for two months which could finally let these vaccines reach poor countries without cold storage and even work as easy skin patches instead of shots.

First human trial of psilocin since the 1960s reveals better tolerability than psilocybin

In a US trial, teclistamab wiped out cancer completely in 78% of high risk myeloma patients, against 0% on standard treatment, and cut two year progression to 8%.

In a trial of 948 people with stomach cancer in 20 countries, adding durvalumab to chemotherapy before and after surgery cut the risk of dying by 22% versus chemo alone.

Retatrutide-Associated Improvements in Cardiovascular Risk Biomarkers in Adults With Obesity With or Without Type 2 Diabetes

Formally recognizing insulin resistance as a distinct disease, rather than just a risk factor, would facilitate earlier diagnosis and standardized treatment.

A trial of 6,238 heart attack survivors in France found stopping beta blockers about as safe as staying on them: 17.2% who stopped had a problem, versus 15.9% who stayed.

In Uganda, 1,784 children under 2 got yellow fever vaccine at full, half or one fifth strength

Treatment of Kratom Withdrawal and Dependence With Buprenorphine/Naloxone: A Case Series and Systematic Literature Review

[JAMA Psychiatry] The EPIsoDE randomized clinical trial of psilocybin for treatment-resistant depression yields inconclusive primary results, finding no statistically significant difference in 6-week response rates between 25 mg psilocybin (17%) and active placebo (10.6%).

Systematic review of 155 studies finds updated COVID-19 vaccines provide meaningful protection against hospitalization and death, especially in older adults

Vaccine protects against multiple fungal infections without hurting gut: Naturally occurring fungi and bacteria in gut microbiome unharmed by new pan-fungal vaccine that achieved protective immunity in primates against life-threatening fungal infections that kill millions each year.

A Czech trial of 558 people with dangerous lung clots found feeding clot dissolving drugs straight into the lung artery cut deaths and repeat clots to under 1%…

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