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One or two psilocybin doses still lifting depression a year on

A single dose of psilocybin, paired with psychological support, provides months of relief from chronic suicidal thoughts in new study

Improvement in advanced Alzheimer’s disease following high-dose psilocybin

Case report: transient return of speech and continence in advanced dementia patient after 5g psilocybin mushrooms

A single dose of psilocybin - the active compound in magic mushrooms - reduces nerve pain for up to a month and makes a widely used painkiller work more effectively, finds a new study in mice

Tobacco plant can produce five psychedelics, including psilocybin and DMT

Human brain changes after first psilocybin use

Repeated doses of psilocybin show promise for treating obsessive-compulsive disorder

A single dose of psilocybin can lead to lasting shifts in a person’s life values, such as an increased appreciation for life and greater self-acceptance

Thousands of Americans Treated With Psilocybin in 2025

Psilocybin might not be the most psychoactive ingredient in magic mushrooms

"A new study suggests Psilocybin may do more than just cause a temporary trip and could actually rewire the brain"

Psilocybin unlocks a specific biological signature in the brain linked to profound mystical states.Scientists found these measurable brain wave changes directly correspond to the intensity of a person’s psychedelic experience.

Low-dose psilocybin reduces weight gain and hyperglycemia in mice fed obesogenic diet

Everything We Knew About Psilocybin's Natural Function May Be Wrong

In clinical trials of psilocybin for anorexia, many patients do not respond to treatment

Microdosing Psilocybin: No Benefit in Cognitive, Affective, or Social Function in Healthy Individuals

Long-term antidepressant effects of psilocybin linked to functional brain changes - a single dose of psilocybin altered the electrical properties of brain cells in rats for months, even after physical changes to the neurons had disappeared.

Psilocybin may reduce depressive symptoms in cancer patients, with mixed effects on anxiety and time-dependent improvements in spiritual well-being and quality of life.

Psilocybin triggers activity-dependent rewiring of large-scale cortical networks

Psilocybin shown to markedly reduce chronic pain and neuroinflammation

A small early-phase human clinical study suggests that a single 10 mg dose of psilocybin transiently reduces compulsive, but not obsessive, symptoms in adults with OCD, with effects peaking at one week and no full psychedelic experience.

A new study shows psilocybin reshapes brain circuits linked to depression by weakening rigid cortico-cortical loops that trap people in negative thinking and strengthening sensory-motor pathways that help restore cognitive flexibility.

Five Years After Psilocybin Therapy, Two-Thirds Remain Free from Depression

Psilocybin therapy linked to reduced suicidal thoughts in people with psychiatric disorders

A single dose of psilocybin shown to rewire brain circuits in mice, providing up to two weeks of relief from both chronic pain and depression-like symptoms, offering a potential non-addictive alternative to opioids

Psilocybin during the postpartum period induces long-lasting adverse effects in both mouse mothers their and offspring

Psilocybin therapy linked to lasting depression remission five years later

Single dose of psilocybin linked to lasting symptom relief in treatment-resistant depression

Researchers tested 12 “magic mushroom” edible products sold in Portland, Ore., and found no trace of psilocybin, the hallucinogenic compound that gives magic mushrooms their name

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